P-glycoprotein and glutathione S-transferase pi in childhood acute lymphoblastic leukaemia
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چکیده
منابع مشابه
Glutathione S-transferases Null Genotype in Acute Myeloid Leukaemia
Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated with several malignancies. Objective: To investigate the rate of GSTT1 and GSTM1 null ge...
متن کاملGlutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia.
The glutathione S-transferase (GST) genes are involved in the metabolism of environmental carcinogens and of some classes of chemotherapy drugs. GSTM1 and GSTT1 genotypes are polymorphic in humans, and the phenotypic absence of enzyme activity is caused by a homozygous inherited deletion of the gene. Previous, smaller studies of childhood acute lymphoblastic leukemia (ALL) provided contrasting ...
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The acquisition of resistance to anticancer agents used in chemotherapy is the main cause of treatment failure in malignant disorders, provoking tumours to become resistant during treatment, although they initially respond to it. The main multidrug resistance (MDR) mechanism in tumour cells is the expression of P-gly-coprotein (P-gly), that acts as an ATP-dependent active efflux pump of chemoth...
متن کاملTerminal deoxynucleotidyl transferase activity in childhood and adult acute lymphoblastic leukaemia.
The measurement of terminal deoxynucleotidyl transferase (TDT) activity in leukaemic blasts of 26 cases of acute lymphoblastic leukaemia (ALL) (13 children less than 14 years, 13 adults greater than 14 years) demonstrated significantly greater activities of the enzyme on a proportion of the adults. The predominant cytological sub-type in the adult patients was L2 (FAB classification) whereas L1...
متن کاملExpression of glutathione, glutathione peroxidase and glutathione S-transferase pi in canine mammary tumors
BACKGROUND Glutathione (GSH) is one of the most important agents of the antioxidant defense system of the cell because, in conjunction with the enzymes glutathione peroxidase (GSH-Px) and glutathione S transferase pi (GSTpi), it plays a central role in the detoxification and biotransformation of chemotherapeutic drugs. This study evaluated the expression of GSH and the GSH-Px and GSTpi enzymes ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1994
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1994.462